Data pre-processing for more effective gene clustering

The high-throughput experimental data from the new gene microarray technology has spurred numerous efforts to find effective ways of processing microarray data for revealing real biological relationships among genes. This work proposes an innovative data pre-processing approach to identify noise data in the data sets and eliminate or reduce the impact of the noise data on gene clustering, With the proposed algorithm, the pre-processed data sets make the clustering results stable across clustering algorithms with different similarity metrics, the important information of genes and features is kept, and the clustering quality is improved. The primary evaluation on real microarray data sets has shown the effectiveness of the proposed algorithm.<br /

Content exploration for e-learning using XML Web services

Obtaining high quality content in an e-learning portal is critical to maximise the learning experience. For e-learning portals the content specialists are the publishers. Typically, publishers are nominated by portal administrators to make their content available to instructors. Instructors subsequently customise the portal by selecting content according to their requirements. The choice of content is limited to that provided by the publishers. This is a rigid system owing to the fact that instructors do not have access to an exhaustive range of content. We propose a system based on XML Web services which can be adopted by publishers in adherence with a number of emerging Web standards including SOAP and UDDI to disseminate their content. This system can be leveraged by portals to preview and subsequently acquire content which best suits the requirements as determined by instructors. <br /

Recognizing emotions induced by wearable haptic vibration using noninvasive electroencephalogram

The integration of haptic technology into affective computing has led to a new field known as affective haptics. Nonetheless, the mechanism underlying the interaction between haptics and emotions remains unclear. In this paper, we proposed a novel haptic pattern with adaptive vibration intensity and rhythm according to the volume, and applied it into the emotional experiment paradigm. To verify its superiority, the proposed haptic pattern was compared with an existing haptic pattern by combining them with conventional visual–auditory stimuli to induce emotions (joy, sadness, fear, and neutral), and the subjects’ EEG signals were collected simultaneously. The features of power spectral density (PSD), differential entropy (DE), differential asymmetry (DASM), and differential caudality (DCAU) were extracted, and the support vector machine (SVM) was utilized to recognize four target emotions. The results demonstrated that haptic stimuli enhanced the activity of the lateral temporal and prefrontal areas of the emotion-related brain regions. Moreover, the classification accuracy of the existing constant haptic pattern and the proposed adaptive haptic pattern increased by 7.71 and 8.60%, respectively. These findings indicate that flexible and varied haptic patterns can enhance immersion and fully stimulate target emotions, which are of great importance for wearable haptic interfaces and emotion communication through haptics

Epigenetic associations with adolescent grey matter maturation and cognitive development

Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly regulated by DNA methylation (DNAm).Methods: We collected brain imaging, cognitive assessments, and DNAm in a longitudinal cohort of approximately 200 typically developing participants, aged 9–14. This data, from three time points roughly 1 year apart, was used to explore the relationships between seven cytosine–phosphate–guanine (CpG) sites in genes highly expressed in brain tissues (GRIN2D, GABRB3, KCNC1, SLC12A9, CHD5, STXBP5, and NFASC), seven networks of grey matter (GM) volume change, and scores from seven cognitive tests.Results: The demethylation of the CpGs as well as the rates of change in DNAm were significantly related to improvements in total, crystalized, and fluid cognition scores, executive function, episodic memory, and processing speed, as well as several networks of GM volume increases and decreases that highlight typical patterns of brain maturation.Discussion: Our study provides a first look at the DNAm of genes involved in myelination, excitatory and inhibitory receptors, and connectivity, how they are related to the large-scale changes occurring in the brain structure as well as cognition during adolescence